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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here. we identify sphingomyelin phosphodiesterase 1 (SMPD1). an enzyme that regulates the conversion of sphingomyelin to ceramide. https://www.diegojavierfares.com/quick-offer-JOMEED-31-5-Square-Coffee-Table-Modern-Farmhouse-Living-Room-Furniture-Beige-p9138-amazing-deal/
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